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Emprumapimod

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Catalog No. T63067Cas No. 765914-60-1
Alias PF-07265803, ARRY-371797

Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.

Emprumapimod

Emprumapimod

🥰Excellent
Purity: 100%
Catalog No. T63067Alias PF-07265803, ARRY-371797Cas No. 765914-60-1
Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.
Pack SizePriceAvailabilityQuantity
1 mg$263In Stock
5 mg$538In Stock
10 mg$859In Stock
50 mg$1,720In Stock
100 mg$2,320In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.
In vivo
In LmnaH222P/H222P mice, Emprumapimod (30 mg/kg; administered orally by gavage; starting at 16 weeks of age and continuing until 20 weeks of age) significantly increased left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD), while reducing FS, a parameter directly proportional to the left ventricular ejection fraction[1].
AliasPF-07265803, ARRY-371797
Chemical Properties
Molecular Weight473.52
FormulaC24H29F2N5O3
Cas No.765914-60-1
SmilesC(C(C)C)N1C=2C(=CC(OC3=C(F)C=C(F)C=C3)=C(C(N[C@@H](CCN(C)C)C(N)=O)=O)C2)C=N1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (168.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1118 mL10.5592 mL21.1184 mL105.5922 mL
5 mM0.4224 mL2.1118 mL4.2237 mL21.1184 mL
10 mM0.2112 mL1.0559 mL2.1118 mL10.5592 mL
20 mM0.1056 mL0.5280 mL1.0559 mL5.2796 mL
50 mM0.0422 mL0.2112 mL0.4224 mL2.1118 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0559 mL

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