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ERDRP-0519

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Purity:98.64%

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COA HNMR HPLC

ERDRP-0519

Catalog No. T24040Cas No. 1374006-96-8

ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.

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Pack Size	Price	Availability
1 mg	$139	In Stock
5 mg	$347	In Stock
10 mg	$488	In Stock
25 mg	$785	In Stock
50 mg	$1,120	In Stock
100 mg	$1,480	In Stock
1 mL x 10 mM (in DMSO)	$382	In Stock

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Product Introduction

Bioactivity

Description	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.
In vitro	ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].
In vivo	A single-dose pharmacokinetic study was conducted in squirrel monkeys through oral administration of ERDRP-0519 at a dose of 50 mg/kg, with blood samples collected at seven predetermined time points following the dose. The peak serum concentrations of ERDRP-0519 were observed approximately 2 hours post-administration, reaching a maximum (Cmax) of 3.27 µM.
Alias	ERDRP0519, ERDRP 0519

Chemical Properties

Molecular Weight	529.58
Formula	C23H30F3N5O4S
Cas No.	1374006-96-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (169.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8883 mL	9.4414 mL	18.8829 mL	94.4144 mL
5 mM	0.3777 mL	1.8883 mL	3.7766 mL	18.8829 mL
10 mM	0.1888 mL	0.9441 mL	1.8883 mL	9.4414 mL
20 mM	0.0944 mL	0.4721 mL	0.9441 mL	4.7207 mL
50 mM	0.0378 mL	0.1888 mL	0.3777 mL	1.8883 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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