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FA16
Catalog No. T64357
Alias FA-16, FA 16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth.
FA16
Catalog No. T64357Alias FA-16, FA 16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $430 | In Stock | |
| 10 mg | $636 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,360 | In Stock | |
| 100 mg | $1,830 | In Stock | |
| 500 mg | $3,680 | In Stock |
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth. |
| Targets&IC50 | Ferroptosis (HT1080 cells):1.26 μM |
| In vitro | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
| In vivo | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
| Alias | FA-16, FA 16 |
| Molecular Weight | 468.54 |
| Formula | C22H27F3N4O2S |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.69 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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