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FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 185 € | In Stock | |
5 mg | 408 € | In Stock | |
10 mg | 604 € | In Stock | |
25 mg | 937 € | In Stock | |
50 mg | 1.292 € | In Stock | |
100 mg | 1.738 € | In Stock | |
500 mg | 3.496 € | In Stock |
Description | FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth. |
Targets&IC50 | Ferroptosis (HT1080 cells):1.26 μM |
In vitro | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
In vivo | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
Alias | FA-16, FA 16 |
Molecular Weight | 468.54 |
Formula | C22H27F3N4O2S |
Smiles | FC(F)(F)C(N=C1C2C=CC=C1)N2CC(CC3)CCN3C4=CC=C(S(N(C)C)(=O)=O)C=C4 |
Storage | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.69 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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