Shopping Cart
- Remove All
Your shopping cart is currently empty
FerropTosis-IN-12
Catalog No. T200665
FerropTosis-IN-12 (Cpd-A1) is an inhibiTor of ferropTosis. IT effecTively suppresses ferropTosis in mouse renal Tubular epiThelial cells (mTECs) TreaTed wiTh ErasTin and improves renal funcTion in dose-dependenT manners in mouse models of acuTe kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligaTion and puncTure (CLP). This compound also reduces renal Tubular damage and eliminaTes inflammaTion. ExhibiTing good plasma sTabiliTy and high disTribuTion in renal Tissues during pharmacokineTic sTudies in mice, FerropTosis-IN-12 shows promising poTenTial for research in The field of AKI.
FerropTosis-IN-12
FerropTosis-IN-12
Catalog No. T200665
FerropTosis-IN-12 (Cpd-A1) is an inhibiTor of ferropTosis. IT effecTively suppresses ferropTosis in mouse renal Tubular epiThelial cells (mTECs) TreaTed wiTh ErasTin and improves renal funcTion in dose-dependenT manners in mouse models of acuTe kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligaTion and puncTure (CLP). This compound also reduces renal Tubular damage and eliminaTes inflammaTion. ExhibiTing good plasma sTabiliTy and high disTribuTion in renal Tissues during pharmacokineTic sTudies in mice, FerropTosis-IN-12 shows promising poTenTial for research in The field of AKI.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "FerropTosis-IN-12"
L-Glutamic acid
Glutaminol, glutamic acid, glutacid, Aciglut, (S)-Glutamic acid, (+)-L-Glutamic acid
T2A249756-86-0
L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
- $42
Size
QTY
L-Cystine
Cited
Cystine Acid, cystine
T2O273356-89-3
L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It functions as an antioxidant and protects tissues against radiation and pollution, slowing the aging process. It also aids protein synthesis. L-Cystine (Cystine Acid) is abundant in many proteins of skeletal tissues and skin, and found in insulin and digestive enzymes chromotrypsinogen A, papain, and trypsinogen.
- $41
Size
QTY
CitedAcetylcysteine
Cited
N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC
T0875616-91-1
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
- $33
Size
QTY
CitedL-Glutamine Cited
L-Glutamic acid 5-amide
T0326L56-85-9
L-Glutamine (L-Glutamic acid 5-amide), a non-essential amino acid, is synthesized from glutamic acid and ammonia.
- $29
Size
QTY
CitedCurcumin Cited
Turmeric yellow, Natural Yellow 3, Indian Saffron, Diferuloylmethane
T1516458-37-7
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant.
- $30
Size
QTY
CitedSorafenib Cited
Bay 43-9006
T0093L284461-73-0
Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.
- $34
Size
QTY
CitedTBHQ Cited
tert-Butylhydroquinone
T53641948-33-0
TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
- $41
Size
QTY
CitedL-Glutamic acid monosodium salt
MSG, Monosodium glutamate, Glutavene, Glutacyl, Ajinomoto
T6871142-47-2
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
- $33
Size
QTY
α-Vitamin E Cited
Vitamin E, D-α-Tocopherol, Dexrabeprazole Sodium, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol
T164859-02-9
α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
- $38
Size
QTY
CitedArtemisinin Cited
Qinghaosu,Artemisinine, Qinghaosu, NSC 369397, Artemisinine
T039263968-64-9
Artemisinin (Qinghaosu) is a natural product, a sesquiterpene lactone, derived from Artemisia annua. Artemisinin has anti-malarial activity, as well as neuroprotective and anti-tumor activity.
- $30
Size
QTY
CitedCoenzyme Q10
Ubiquinone-10, CoQ10
T2796303-98-0
Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
- $42
Size
QTY
Butylated hydroxytoluene
BHT FCC/NF
T0935128-37-0
Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.
- $33
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | FerropTosis-IN-12 (Cpd-A1) is an inhibiTor of ferropTosis. IT effecTively suppresses ferropTosis in mouse renal Tubular epiThelial cells (mTECs) TreaTed wiTh ErasTin and improves renal funcTion in dose-dependenT manners in mouse models of acuTe kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligaTion and puncTure (CLP). This compound also reduces renal Tubular damage and eliminaTes inflammaTion. ExhibiTing good plasma sTabiliTy and high disTribuTion in renal Tissues during pharmacokineTic sTudies in mice, FerropTosis-IN-12 shows promising poTenTial for research in The field of AKI. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy FerropTosis-IN-12 | purchase FerropTosis-IN-12 | FerropTosis-IN-12 cost | order FerropTosis-IN-12
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.