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FFN246
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Catalog No. T78684Cas No. 2210244-83-8
FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra at 392/427 nm, respectively. It serves to label serotonergic neurons within mouse brain tissue via SERT-dependent accumulation [1].
FFN246
😃Good
Catalog No. T78684Cas No. 2210244-83-8
FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra at 392/427 nm, respectively. It serves to label serotonergic neurons within mouse brain tissue via SERT-dependent accumulation [1].
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra at 392/427 nm, respectively. It serves to label serotonergic neurons within mouse brain tissue via SERT-dependent accumulation [1]. |
| In vivo | FFN246, at concentrations ranging from 2.5 to 20 μM and a 30-minute incubation, can be employed for direct detection of serotonin transporter (SERT) activity and SERT inhibitors in 96-well plate cell culture assays. It can also specifically label serotonergic neurons in the dorsal raphe nucleus within acute mouse brain slices [1]. Additionally, FFN246 at 20 μM for 30 minutes effectively traces serotonin uptake and packaging in the somata of serotonergic neurons [1]. |
| Molecular Weight | 256.27 |
| Formula | C15H13FN2O |
| Cas No. | 2210244-83-8 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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