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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $63 | In Stock | |
2 mg | $89 | In Stock | |
5 mg | $128 | In Stock | |
10 mg | $183 | In Stock | |
25 mg | $329 | In Stock | |
50 mg | $473 | In Stock | |
100 mg | $675 | In Stock | |
1 mL x 10 mM (in DMSO) | $152 | In Stock |
Description | GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. |
Alias | ARRY-575, GDC-0575, GDC 0575, ARRY575, GDC0575 |
Molecular Weight | 414.73 |
Formula | C16H21BrClN5O |
Cas No. | 1196504-54-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/ml (144.67 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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