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GX-585
🥰Excellent
Catalog No. T69915Cas No. 2098540-08-8
Alias GX585, GX 585
GX-585 is a sulfonamide analog that is a Nav 1.7 channel inhibitor with analgesic activity for the study of neuropathic pain and inflammation.
GX-585
🥰Excellent
Purity: 100%
Catalog No. T69915Alias GX585, GX 585Cas No. 2098540-08-8
GX-585 is a sulfonamide analog that is a Nav 1.7 channel inhibitor with analgesic activity for the study of neuropathic pain and inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $719 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,490 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,750 | In Stock |
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Purity:100%
ee:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GX-585 is a sulfonamide analog that is a Nav 1.7 channel inhibitor with analgesic activity for the study of neuropathic pain and inflammation. |
| Targets&IC50 | Nav1.8:11.7μM |
| In vitro | GX-585 is a potent inhibitor of NaV1.7 and highly selective for NaV1.5, but has different selectivity among neuronal NaV channels, with weaker inhibition of tetrodotoxin-resistant sodium currents in mouse DRG neurons, indicating weaker affinity for NaV1.8, with GX-585 blocking IC50 of 11.7 μM.[1] |
| In vivo | METHODS: In an animal model of acute injury, the effects of once daily (q.d.) oral administration of 3 mg/kg and 10 mg/kg GX-585 were evaluated 2 hours after the first, fifth, or twelfth daily dose. RESULTS: A single 10 mg/kg dose of GX-585 produced analgesic effects similar to repeated 3 mg/kg doses 2 hours after administration, but the activity was completely reversed after 24 hours. Thus, the long-term effects of repeated dosing are inconsistent with slow losses of the compound from plasma. [1] |
| Alias | GX585, GX 585 |
| Molecular Weight | 539.45 |
| Formula | C24H25Cl2FN4O3S |
| Cas No. | 2098540-08-8 |
| Smiles | CC=1C=2C(N(N1)[C@H]3CN([C@H](C)C4=CC(Cl)=CC(Cl)=C4)CC3)=CC(F)=C(C(NS(=O)(=O)C5CC5)=O)C2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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