Shopping Cart

Remove All

Your shopping cart is currently empty

GX-585

Select Batch

Purity:100%

ee:99.76%

Resource Download

COA CSFC FNMR HNMR HPLC LCMS

GX-585

Catalog No. T69915Cas No. 2098540-08-8

GX-585 is a sulfonamide analog that is a Nav 1.7 channel inhibitor with analgesic activity for the study of neuropathic pain and inflammation.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	GX-585 is a sulfonamide analog that is a Nav 1.7 channel inhibitor with analgesic activity for the study of neuropathic pain and inflammation.
In vitro	GX-585 is a potent inhibitor of NaV1.7 and highly selective for NaV1.5, but has different selectivity among neuronal NaV channels, with weaker inhibition of tetrodotoxin-resistant sodium currents in mouse DRG neurons, indicating weaker affinity for NaV1.8, with GX-585 blocking IC50 of 11.7 μM.[1]
In vivo	METHODS: In an animal model of acute injury, the effects of once daily (q.d.) oral administration of 3 mg/kg and 10 mg/kg GX-585 were evaluated 2 hours after the first, fifth, or twelfth daily dose. RESULTS: A single 10 mg/kg dose of GX-585 produced analgesic effects similar to repeated 3 mg/kg doses 2 hours after administration, but the activity was completely reversed after 24 hours. Thus, the long-term effects of repeated dosing are inconsistent with slow losses of the compound from plasma. [1]
Alias	GX585, GX 585

Chemical Properties

Molecular Weight	539.45
Formula	C24H25Cl2FN4O3S
Cas No.	2098540-08-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc