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Hydroxybupropion

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Catalog No. T11588Cas No. 92264-81-8
Alias Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion

Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).

Hydroxybupropion

Hydroxybupropion

🥰Excellent
Catalog No. T11588Alias Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-HydroxybupropionCas No. 92264-81-8
Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
Pack SizePriceAvailabilityQuantity
1 mg$119 In Stock
2 mg$176 In Stock
5 mg$297 In Stock
10 mg$463 In Stock
25 mg$743 In Stock
50 mg$987 In Stock
100 mg$1,370 In Stock
1 mL x 10 mM (in DMSO)$297 In Stock
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Product Introduction

Bioactivity
Description
Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
Targets&IC50
Norepinephrine uptake:1.7 μM
In vitro
Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1].
AliasHydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion
Chemical Properties
Molecular Weight255.74
FormulaC13H18ClNO2
Cas No.92264-81-8
SmilesC(C(NC(CO)(C)C)C)(=O)C1=CC(Cl)=CC=C1
Relative Density.1.15 g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (351.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9102 mL19.5511 mL39.1022 mL195.5111 mL
5 mM0.7820 mL3.9102 mL7.8204 mL39.1022 mL
10 mM0.3910 mL1.9551 mL3.9102 mL19.5511 mL
20 mM0.1955 mL0.9776 mL1.9551 mL9.7756 mL
50 mM0.0782 mL0.3910 mL0.7820 mL3.9102 mL
100 mM0.0391 mL0.1955 mL0.3910 mL1.9551 mL

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