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Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $119 | In Stock | |
2 mg | $176 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $463 | In Stock | |
25 mg | $743 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,370 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM). |
Targets&IC50 | Norepinephrine uptake:1.7 μM |
In vitro | Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1]. |
Alias | Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion |
Molecular Weight | 255.74 |
Formula | C13H18ClNO2 |
Cas No. | 92264-81-8 |
Smiles | C(C(NC(CO)(C)C)C)(=O)C1=CC(Cl)=CC=C1 |
Relative Density. | 1.15 g/cm3 |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (351.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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