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iFSP1
🥰Excellent
Catalog No. T11631Cas No. 150651-39-1
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
iFSP1
🥰Excellent
Purity: 99.74%
Catalog No. T11631Cas No. 150651-39-1
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $29 | In Stock | |
| 10 mg | $42 | In Stock | |
| 25 mg | $95 | In Stock | |
| 50 mg | $175 | In Stock | |
| 100 mg | $328 | In Stock |
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CitedSelect Batch
Purity:99.74%
Contact us for more batch information
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1. |
| Targets&IC50 | FSP1:103 nM (EC50) |
| In vitro | iFSP1 (0.001-1 μM; 24 hours) is less effective than genetic deletion of FSP1, and its treatment in the FSP1-knockout background does not enhance RSL3-induced ferroptosis. iFSP1 (3 μM; 24 hours) causes significant toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines. AIFM2, now renamed ferroptosis suppressor protein 1 (FSP1), is identified as a previously unrecognized anti-ferroptotic gene. iFSP1 (0.001-1 μM; 24 hours) inhibits the growth of Gpx4-knockout cells in a dose-dependent manner but does not affect wild type cells. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4-knockout cells from iFSP1-induced ferroptosis. |
| Molecular Weight | 323.35 |
| Formula | C20H13N5 |
| Cas No. | 150651-39-1 |
| Smiles | Cc1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (77.32 mM), Sonification is recommended.（The compound is unstable in solution, please use soon.） | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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