Shopping Cart
- Remove All
Your shopping cart is currently empty
IRL-1620 acetate
🥰Excellent
Catalog No. T15595L
Alias IRL-1620 acetate（142569-99-1 free base）
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
IRL-1620 acetate
🥰Excellent
Purity: 96.64%
Catalog No. T15595LAlias IRL-1620 acetate（142569-99-1 free base）
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $189 | In Stock | |
| 5 mg | $469 | In Stock | |
| 10 mg | $687 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,450 | In Stock | |
| 100 mg | $1,960 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "IRL-1620 acetate"
Ambrisentan
LU 208075, BSF-208075, BSF 208075
T1655177036-94-1
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury.
- $30
Size
QTY
Bosentan
Cited
Ro 47-0203, Benzenesulfonamide, Actelion
T6264147536-97-8
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
- $32
Size
QTY
CitedBMS 182874 hydrochloride
T217901215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
- $74
Size
QTY
Sparsentan
RE-021, DARA-a
T5355254740-64-2
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
- $33
Size
QTY
Aprocitentan
ACT-132577
T78171103522-45-7
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
- $53
Size
QTY
Macitentan
ACT-064992
T2561441798-33-0
Macitentan (ACT-064992) is an endothelin receptor antagonist utilized in the treatment of pulmonary arterial hypertension (PAH).
- $37
Size
QTY
Sitaxsentan sodium
Thelin, TBC11251 sodium salt, TBC11251, Sitaxentan sodium
T6672210421-74-2
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
- $30
Size
QTY
Clazosentan
VML 588, Ro 61-1790, AXV-034343
T64084180384-56-9In house
Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction.
- $84
Size
QTY
BMS 182874
BMS-182874, BMS182874
T26841153042-42-3
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
- $68
Size
QTY
Edonentan
BMS-207940, BMS207940, BMS 207940
T31605210891-04-6In house
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
- $988
Size
QTY
Nebentan potassium
YM598
T36008342005-82-7In house
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
- $84
Size
QTY
Sitaxsentan
TBC-11251, IPI 1040
T12924184036-34-8
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful effects of endothelin.
- $91
Size
QTY
Select Batch
Purity:96.64%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM. |
| Targets&IC50 | ETB receptor:16 pM(Ki), ETA receptor:19 μM(Ki) |
| In vitro | IRL-1620 acetate is 60 times more selective for the ETB receptor than ET-3 (KiETA/ KiETB=1900)[3]. |
| In vivo | IRL-1620 acetate improves both acquisition (learning) and retention (memory) on the water maze task and enhances angiogenic and neurogenic remodeling. Rats treated with IRL-1620 acetate significantly reduces the cognitive impairment induced by Aβ. IRL-1620 acetate treatment enhances the number of blood vessels labeled with VEGF compared to vehicle treatment[1]. IRL-1620 acetate, restores analgesic tolerance to morphine and oxycodone, but it does not affect morphine and oxycodone induced decrease in NGF/PI3K expression. IRL-1620 acetate attenuates opioid tolerance without the involvement of NGF/PI3K pathway[2]. IRL-1620 acetate (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL 1620[3]. IRL-1620 acetate (1-100 nM) increases cytosolic Ca2+ in the vascular endothelium ([Ca]E) with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone with an increase in [Ca]E, in rat aorta[3]. |
| Alias | IRL-1620 acetate（142569-99-1 free base） |
| Molecular Weight | 1881 |
| Formula | C88H121N17O29 |
| Smiles | CC(O)=O.O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC3=CNC=N3)NC([C@H](C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy IRL-1620 acetate | purchase IRL-1620 acetate | IRL-1620 acetate cost | order IRL-1620 acetate | IRL-1620 acetate chemical structure | IRL-1620 acetate in vivo | IRL-1620 acetate in vitro | IRL-1620 acetate formula | IRL-1620 acetate molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.