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Isocarboxazid

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Purity:99.94%

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COA HNMR HPLC

Isocarboxazid

Catalog No. T4559Cas No. 59-63-2

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[2] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders.

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Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$72	In Stock
10 mg	$97	In Stock
25 mg	$176	In Stock
50 mg	$262	In Stock
100 mg	$389	In Stock
500 mg	$883	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[2] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic
In vitro	In vivo studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]
In vivo	In vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]

Chemical Properties

Molecular Weight	231.25
Formula	C12H13N3O2
Cas No.	59-63-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (216.22 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3243 mL	21.6216 mL	43.2432 mL	216.2162 mL
5 mM	0.8649 mL	4.3243 mL	8.6486 mL	43.2432 mL
10 mM	0.4324 mL	2.1622 mL	4.3243 mL	21.6216 mL
20 mM	0.2162 mL	1.0811 mL	2.1622 mL	10.8108 mL
50 mM	0.0865 mL	0.4324 mL	0.8649 mL	4.3243 mL
100 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1622 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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