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Isoimperatorin

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Purity:99.93%

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COA HNMR HPLC

Isoimperatorin

Catalog No. T2846Cas No. 482-45-1

Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).

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Pack Size	Price	Availability
25 mg	$41	In Stock
50 mg	$66	In Stock
100 mg	$97	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
Targets&IC50	AChE:74.6 μM.
In vitro	The ethanol extract from Notopterygium incisum rhizomes displays significant nematicidal activity against nematodes Bursaphelenchus xylophilus and Meloidogyne incognita, discovered during a search for new agrochemicals from Chinese medicinal herbs. Four components—Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin—were isolated and identified from the extract via bioactivity-guided fractionation. Isoimperatorin exhibited notable efficacy with an LC50 value of 21.83 μg/mL against B. xylophilus. Under 15 min UV light exposure, Falcarindiol, Falcarinol, and Isoimperatorin showed nearly quintuple toxicity increase toward southern root-knot nematodes compared to dark conditions, whereas Columbianetin's toxicity doubled. Additionally, Isoimperatorin has been proven to have insecticidal properties against various insects, including the cabbage aphid (Brevicoryne brassicae). It has been found in the active fraction of Angelica dahurica (AD) extract and is frequently used as the internal standard (IS) in assays.

Chemical Properties

Molecular Weight	270.28
Formula	C16H14O4
Cas No.	482-45-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mg/mL (37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6999 mL	18.4993 mL	36.9987 mL	184.9933 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL	36.9987 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL	18.4993 mL
20 mM	0.1850 mL	0.9250 mL	1.8499 mL	9.2497 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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