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Isoimperatorin
Catalog No. T2846Cas No. 482-45-1
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
Isoimperatorin
Catalog No. T2846Cas No. 482-45-1
Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $41 | In Stock | |
| 50 mg | $66 | In Stock | |
| 100 mg | $97 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock |
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Purity:99.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE). |
| Targets&IC50 | AChE:74.6 μM. |
| In vitro | The ethanol extract from Notopterygium incisum rhizomes displays significant nematicidal activity against nematodes Bursaphelenchus xylophilus and Meloidogyne incognita, discovered during a search for new agrochemicals from Chinese medicinal herbs. Four components—Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin—were isolated and identified from the extract via bioactivity-guided fractionation. Isoimperatorin exhibited notable efficacy with an LC50 value of 21.83 μg/mL against B. xylophilus. Under 15 min UV light exposure, Falcarindiol, Falcarinol, and Isoimperatorin showed nearly quintuple toxicity increase toward southern root-knot nematodes compared to dark conditions, whereas Columbianetin's toxicity doubled. Additionally, Isoimperatorin has been proven to have insecticidal properties against various insects, including the cabbage aphid (Brevicoryne brassicae). It has been found in the active fraction of Angelica dahurica (AD) extract and is frequently used as the internal standard (IS) in assays. |
| Molecular Weight | 270.28 |
| Formula | C16H14O4 |
| Cas No. | 482-45-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (37 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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