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Product Introduction

Bioactivity

Description	Isosorbide (Devicoran) is a heterocyclic compound that is derived from glucose, used as a diuretic.
In vitro	Isosorbide increases urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma. Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased. [1]
Alias	Isobide, Hydronol, D-Isosorbide, Dianhydro-D-glucitol, Devicoran

Chemical Properties

Molecular Weight	146.14
Formula	C₆H₁₀O₄
Cas No.	652-67-5
Smiles	O[C@@H]1[C@@]2([C@@]([C@H](O)CO2)(OC1)[H])[H]
Relative Density.	1.0945 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (342.14 mM)

H2O: 100 mg/mL (684.28 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.8428 mL	34.2138 mL	68.4275 mL	342.1377 mL
5 mM	1.3686 mL	6.8428 mL	13.6855 mL	68.4275 mL
10 mM	0.6843 mL	3.4214 mL	6.8428 mL	34.2138 mL
20 mM	0.3421 mL	1.7107 mL	3.4214 mL	17.1069 mL
50 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8428 mL
100 mM	0.0684 mL	0.3421 mL	0.6843 mL	3.4214 mL

Calculator

Molarity Calculator
Dilution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

vasodilatingpainIsosorbideInhibitorinhibithyperosmoticheartfailurediureticchestangina