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Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $81 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $313 | In Stock | |
25 mg | $629 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,590 | In Stock | |
200 mg | $2,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $217 | In Stock |
Description | Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease. |
Targets&IC50 | JAK3:9.5(pKi), JAK1:10.0(pKi), JAK2:8.8 (pKi) |
In vitro | Izencitinib ( TD-1473 ), as an effective inhibitor of JAK1, JAK2 and JAK3, can act on the human JAK kinase domain ( pKi values are 10.0,8.8 and 9.5, respectively )[1]. |
In vivo | Izencitinib ( TD-1473,1 mg / kg BID ) can be used in oxazolone-induced colitis in mice[1]. |
Alias | TD-1473, JNJ-8398 |
Molecular Weight | 402.50 |
Formula | C22H26N8 |
Cas No. | 2051918-33-1 |
Smiles | Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)n2)n[nH]1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (74.53 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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