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Izencitinib
Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.
Catalog No. T35898Cas No. 2051918-33-1
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Purity:99.82%
ee:100%
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Izencitinib
Catalog No. T35898Alias TD-1473, JNJ-8398Cas No. 2051918-33-1
Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease. |
| Targets&IC50 | JAK3:9.5(pKi), JAK2:8.8 (pKi), JAK1:10.0(pKi) |
| In vitro | Izencitinib ( TD-1473 ), as an effective inhibitor of JAK1, JAK2 and JAK3, can act on the human JAK kinase domain ( pKi values are 10.0,8.8 and 9.5, respectively )[1]. |
| In vivo | Izencitinib ( TD-1473,1 mg / kg BID ) can be used in oxazolone-induced colitis in mice[1]. |
| Alias | TD-1473, JNJ-8398 |
| Molecular Weight | 402.50 |
| Formula | C22H26N8 |
| Cas No. | 2051918-33-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (74.53 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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