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LCB 03-0110 dihydrochloride

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Purity:99.76%

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COA HPLC HNMR

LCB 03-0110 dihydrochloride

Catalog No. T32613Cas No. 1962928-28-4

LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.

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Pack Size	Price	Availability
1 mg	$71	In Stock
2 mg	$106	In Stock
5 mg	$163	In Stock
10 mg	$238	In Stock
25 mg	$397	In Stock
50 mg	$568	In Stock
100 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.
In vitro	LCB 03-0110 treatment of cells exposed to TGF-β1 and type I collagen showed a marked inhibition preferentially in the phosphorylation of tyrosine 861, to give approximately 50% reduction at 1 μM and an almost complete abolishment at 3 μM.

Chemical Properties

Molecular Weight	490.45
Formula	C24H25Cl2N3O2S
Cas No.	1962928-28-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (61.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0389 mL	10.1947 mL	20.3894 mL	101.9472 mL
5 mM	0.4078 mL	2.0389 mL	4.0779 mL	20.3894 mL
10 mM	0.2039 mL	1.0195 mL	2.0389 mL	10.1947 mL
20 mM	0.1019 mL	0.5097 mL	1.0195 mL	5.0974 mL
50 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0389 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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