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LM10

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Purity:99.94%

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COA LCMS HNMR

LM10

Catalog No. T4410Cas No. 1316695-35-8

Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$81	In Stock
50 mg	$147	In Stock
100 mg	$247	In Stock
200 mg	$368	In Stock
500 mg	$596	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	229.21
Formula	C11H8FN5
Cas No.	1316695-35-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 4.58 mg/mL(20 mM)

DMSO: 70 mg/mL (305.4 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.3628 mL	21.8141 mL	43.6281 mL	218.1406 mL
5 mM	0.8726 mL	4.3628 mL	8.7256 mL	43.6281 mL
10 mM	0.4363 mL	2.1814 mL	4.3628 mL	21.8141 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2181 mL	1.0907 mL	2.1814 mL	10.9070 mL
50 mM	0.0873 mL	0.4363 mL	0.8726 mL	4.3628 mL
100 mM	0.0436 mL	0.2181 mL	0.4363 mL	2.1814 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc