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LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
🥰Excellent
Catalog No. T7676
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β .
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
🥰Excellent
Catalog No. T7676
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $37 | In Stock | |
| 5 mg | $52 | In Stock | |
| 10 mg | $81 | In Stock | |
| 25 mg | $148 | In Stock | |
| 50 mg | $229 | In Stock | |
| 100 mg | $352 | In Stock | |
| 200 mg | $492 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $89 | In Stock |
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Purity:≥98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β . |
| In vivo | Administration of LSKL peptide attenuated Smad2 phosphorylation at 6 h. S-phase entry of hepatocytes was accelerated at 24 and 48 h by LSKL peptide, which resulted in faster recovery of the residual liver and bodyweight.?Haematoxylin and eosin tissue staining and blood biochemical examinations revealed no significant adverse effects following the two LSKL peptide administrations.?In the clinical setting, plasma TSP-1 levels were lowest on the first day after hepatectomy.?However, plasma TSP-1 levels at this stage were significantly higher in patients with subsequent liver dysfunction compared with levels in those without liver dysfunction following hepatectomy |
| Animal Research | Mice were operated on with a 70 per cent hepatectomy or sham procedure. Operated mice received either LSKL peptide or normal saline intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by enzyme-linked immunosorbent assay in patients undergoing hepatectomy. |
| Molecular Weight | 686.64 |
| Formula | C25H44F6N6O9 |
| Smiles | CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@@H](N)CC(C)C)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (40.05 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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