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LY-402913

🥰Excellent
Catalog No. T27954Cas No. 334970-65-9
Alias LY402913, LY 402913

LY-402913 is a selective inhibitor of the multidrug resistance protein (MRP1).

LY-402913

LY-402913

🥰Excellent
Purity: 100%
Catalog No. T27954Alias LY402913, LY 402913Cas No. 334970-65-9
LY-402913 is a selective inhibitor of the multidrug resistance protein (MRP1).
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
2 mg$175In Stock
5 mg$268In Stock
10 mg$395In Stock
25 mg$592In Stock
50 mg$828In Stock
100 mg$1,130In Stock
1 mL x 10 mM (in DMSO)$337In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
LY-402913 is a selective inhibitor of the multidrug resistance protein (MRP1).
In vitro
LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (∼22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2].
In vivo
When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2].
AliasLY402913, LY 402913
Chemical Properties
Molecular Weight533.96
FormulaC28H24ClN3O6
Cas No.334970-65-9
SmilesO=C1N(C=2C(C3=C1C(C)=NO3)=C(Cl)C=CC2)C4=CC(CC(NC5=CC(OC)=C(OC)C(OC)=C5)=O)=CC=C4
Relative Density.1.376 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (93.64 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8728 mL9.3640 mL18.7280 mL93.6400 mL
5 mM0.3746 mL1.8728 mL3.7456 mL18.7280 mL
10 mM0.1873 mL0.9364 mL1.8728 mL9.3640 mL
20 mM0.0936 mL0.4682 mL0.9364 mL4.6820 mL
50 mM0.0375 mL0.1873 mL0.3746 mL1.8728 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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