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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $36 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $59 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $289 | In Stock | |
100 mg | $428 | In Stock | |
200 mg | $623 | In Stock | |
1 mL x 10 mM (in DMSO) | $66 | In Stock |
Description | MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent. |
In vitro | MAC-545496 could also serve as an antivirulence agent alone;?it attenuates MRSA virulence in Galleria mellonella larvae.?MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.?Mechanistic characterization revealed MAC-545496 to be a nanomolar inhibitor of GraR, a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance. |
Molecular Weight | 419.89 |
Formula | C18H18ClN5O3S |
Cas No. | 838810-96-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (595.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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