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MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2mg (26.99mM*200ul in methyl acetate) | 93 € | 5 days | |
5mg (26.99mM*500ul in methyl acetate) | 228 € | 5 days | |
10mg (26.99mM*1ml in methyl acetate) | 342 € | 5 days |
Description | MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2. |
In vitro | In a concentration-dependent manner after a 5 min preincubation at 40°C in P388D1 cells, MAFP inhibits iPLA2 (IC50: 5 μM). MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP shows selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. cPLA is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2]. |
Alias | Methyl Arachidonyl Fluorophosphonate |
Molecular Weight | 370.48 |
Formula | C21H36FO2P |
Cas No. | 188404-10-6 |
Smiles | C(/C=C\C/C=C\C/C=C\C/C=C\CCCCC)CCCP(OC)(F)=O |
Relative Density. | 0.960 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Methyl Acetate: 9.0 mg/mL (24.3 mM) DMSO: 90.0 mg/mL (242.9 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Methyl Acetate/DMSO
DMSO
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