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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $82 | In Stock | |
5 mg | $197 | In Stock |
Description | Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells. |
In vitro | Here we observed that of the three tested lignan molecules, Matairesinol (MAT) was the most effective as a death receptor-sensitizing agent. MAT sensitized the androgen-dependent LNCaP cells to TRAIL-induced apoptosis both in the presence and absence of androgens. Treatment with MAT markedly decreased Akt activity, which has been implicated as a key signaling mechanism in the TRAIL resistance of LNCaP prostate cancer cells. The involvement of the pathway in the MAT-mediated sensitization was shown in rescue experiments using ectopic expression of constitutively active Akt[1] |
Molecular Weight | 358.39 |
Formula | C20H22O6 |
Cas No. | 580-72-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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