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Methiothepin maleate
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Catalog No. T4375Cas No. 19728-88-2
Alias Metitepine
Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Methiothepin maleate
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Catalog No. T4375Alias MetitepineCas No. 19728-88-2
Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $78 | 35 days | |
| 25 mg | $175 | 35 days | |
| 50 mg | $250 | 35 days | |
| 100 mg | $460 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. |
| Targets&IC50 | H5-HT7 receptor:152 nM |
| In vivo | The intracerebroventricular administration of aftin-4 (3–20 nmol) increased Aβ1-42, but not Aβ1-40, content in the mouse hippocampus, between 5 and 14 days after injection. Aftin-4 injection increased lipid peroxidation levels in the hippocampus, an index of oxidative stress. |
| Alias | Metitepine |
| Molecular Weight | 472.62 |
| Formula | C24H28N2O4S2 |
| Cas No. | 19728-88-2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mM | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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