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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $32 | In Stock | |
5 mg | $51 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $182 | In Stock | |
50 mg | $318 | In Stock | |
100 mg | $479 | In Stock | |
1 mL x 10 mM (in DMSO) | $58 | In Stock |
Description | MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1]. |
In vitro | MK2-IN-1 has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50: 4.4 μM) and IL-6 (IC50: 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrix-metalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50: 5.7 μM) and human primary chondrocyte cultures (IC50: 2.2 μM) [1]. |
Alias | MK2 Inhibitor, MK 25 |
Molecular Weight | 509.43 |
Formula | C27H26Cl2N4O2 |
Cas No. | 1314118-94-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 50 mg/mL (98.15 mM) H2O: Insoluble | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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