Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 189.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 537.00 | |
50 mg | In stock | $ 775.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | In stock | $ 2,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways. |
In vitro | ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively[1]. |
Molecular Weight | 319.4 |
Formula | C20H21N3O |
CAS No. | 451496-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
DMSO: 5 mg/ml
DMF: 25 mg/ml
Ethanol: 10 mg/ml
You can also refer to dose conversion for different animals. More
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ML-148 451496-96-1 Metabolism Dehydrogenase selective Inhibitor prostaglandin-signaling 15-PGDH 15-Hydroxyprostaglandin dehydrogenase ML 148 NAD+ PGE2 inhibit ML148 inhibitor