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MSDC-0602K

🥰Excellent
Catalog No. T38715Cas No. 1314533-27-1
Alias MSDC-0602K, Azemiglitazone potassium

MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.

MSDC-0602K

MSDC-0602K

🥰Excellent
Purity: 99.89%
Catalog No. T38715Alias MSDC-0602K, Azemiglitazone potassiumCas No. 1314533-27-1
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.
Pack SizePriceAvailabilityQuantity
1 mg$55In Stock
5 mg$123In Stock
10 mg$196In Stock
25 mg$392In Stock
50 mg$629In Stock
100 mg$886In Stock
500 mg$1,770In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.
Targets&IC50
PPARγ:18.25 μM
In vivo
Diabetic db/db and MS-NASH mice are treated with MSDC-0602K via oral gavage, Liraglutide via s.c. injection, or a combination of MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis. Animal Model: Five-week-old male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice [1]. Dosage: 30 mg/kg MSDC-0602K and 0.2 mg/kg Liraglutide. Administration: MSDC-0602K gavage daily, Liraglutide s.c. every other day, or combined MSDC-0602K + Liraglutide. Result: MSDC-0602K alone corrected glycemia and reduced insulinemia, while the combination with Liraglutide significantly improved glucose tolerance and liver histology[1].
AliasMSDC-0602K, Azemiglitazone potassium
Chemical Properties
Molecular Weight409.5
FormulaC19H16KNO5S
Cas No.1314533-27-1
SmilesCOC1=CC=CC(=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)[N-]C(=O)S3.[K+]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (122.1 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4420 mL12.2100 mL24.4200 mL122.1001 mL
5 mM0.4884 mL2.4420 mL4.8840 mL24.4200 mL
10 mM0.2442 mL1.2210 mL2.4420 mL12.2100 mL
20 mM0.1221 mL0.6105 mL1.2210 mL6.1050 mL
50 mM0.0488 mL0.2442 mL0.4884 mL2.4420 mL
100 mM0.0244 mL0.1221 mL0.2442 mL1.2210 mL

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