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NFAT Transcription Factor Regulator-1

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Purity:99.11%

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COA HNMR HPLC

NFAT Transcription Factor Regulator-1

Catalog No. T12218Cas No. 245747-71-1

NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$85	In Stock
10 mg	$145	In Stock
25 mg	$269	In Stock
50 mg	$397	In Stock
100 mg	$568	In Stock
500 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Product Introduction

Bioactivity

Description	NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).
In vitro	NFAT Transcription Factor Regulator-1 inhibits IL-2 synthesis(IC50 of 182 nM). NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release.
In vivo	NFAT Transcription Factor Regulator-1 demonstrates an inhibitory potency on T-cell IL-2 production that is approximately 10 times greater than cyclosporine, requiring doses of 3.0 mg/kg and 30 mg/kg, respectively, for comparable effects. In vivo studies in monkeys further reveal the potential of NFAT Transcription Factor Regulator-1 to block T-cell cytokine production effectively, suggesting its viability as a transplantation aid comparable to cyclosporine[1].

Chemical Properties

Molecular Weight	416.28
Formula	C17H10F6N4O2
Cas No.	245747-71-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (120.11 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4022 mL	12.0111 mL	24.0223 mL	120.1115 mL
5 mM	0.4804 mL	2.4022 mL	4.8045 mL	24.0223 mL
10 mM	0.2402 mL	1.2011 mL	2.4022 mL	12.0111 mL
20 mM	0.1201 mL	0.6006 mL	1.2011 mL	6.0056 mL
50 mM	0.0480 mL	0.2402 mL	0.4804 mL	2.4022 mL
100 mM	0.0240 mL	0.1201 mL	0.2402 mL	1.2011 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc