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NKH477
🥰Excellent
Catalog No. T16332Cas No. 138605-00-2
Alias NKH 477, Colforsin dapropate hydrochloride
NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity. It inhibits ACh-induced Ca2+ mobilization by acting on ionomycin-sensitive storage sites. NKH477 is an adenylyl cyclase activator with bronchodilatory effects, inhibiting the production of CTL, T-cell proliferation in mixed lymphocyte reactions (MLR), as well as IL-2 production and mitogen responses.
NKH477
🥰Excellent
Purity: 98%
Catalog No. T16332Alias NKH 477, Colforsin dapropate hydrochlorideCas No. 138605-00-2
NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity. It inhibits ACh-induced Ca2+ mobilization by acting on ionomycin-sensitive storage sites. NKH477 is an adenylyl cyclase activator with bronchodilatory effects, inhibiting the production of CTL, T-cell proliferation in mixed lymphocyte reactions (MLR), as well as IL-2 production and mitogen responses.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity. It inhibits ACh-induced Ca2+ mobilization by acting on ionomycin-sensitive storage sites. NKH477 is an adenylyl cyclase activator with bronchodilatory effects, inhibiting the production of CTL, T-cell proliferation in mixed lymphocyte reactions (MLR), as well as IL-2 production and mitogen responses. |
| In vitro | NKH477 (0.1-1.0 μM) inhibits ACh induced contraction in a concentration-dependent manner by attenuating ACh induced Ca2 + mobilization and reducing the sensitivity of the contractile mechanism to Ca2 +. [1] |
| In vivo | In experimental dogs, intravenous administration of NKH477 (1-30 μg/kg) resulted in an increase in left ventricular dP/dtmax, coronary and femoral blood flow, heart rate, and myocardial oxygen consumption, as well as a decrease in blood pressure in anesthetized dogs. NKH477 is a useful insulin dilator for the treatment of heart failure. [2] |
| Alias | NKH 477, Colforsin dapropate hydrochloride |
| Molecular Weight | 546.09 |
| Formula | C27H44ClNO8 |
| Cas No. | 138605-00-2 |
| Smiles | O[C@@]12[C@]3(C)[C@@]([C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@@]1(C)O[C@](C=C)(C)CC2=O)(C(C)(C)CC[C@@H]3O)[H].Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (146.5 mM), Sonication is recommended. H2O: 10 mg/mL (18.31 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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