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NNC 05-2090 hydrochloride

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Purity:99.05%

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COA HPLC HNMR

NNC 05-2090 hydrochloride

Catalog No. T23072Cas No. 184845-18-9

NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders.

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Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$105	In Stock
10 mg	$172	In Stock
25 mg	$389	In Stock
50 mg	$697	In Stock
100 mg	$1,080	In Stock

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Product Introduction

Bioactivity

Description	NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders.
In vitro	NNC05-2090 hydrochloride binds to prazosin and spiperone with IC50 values of 266 nM and 1632 nM, respectively.[1] NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in rat cortical synaptosomes with an IC50 value of 4.4 μM.[1] NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in inferior colliculus synaptosomes with an IC50 value of 2.5 μM.[1] NNC05-2090 hydrochloride inhibits serotonin, norepinephrine, dopamine transporter, and BGT-1 with IC50 values of 5.29, 7.91, 4.08, and 10.6 μM respectively.[1] NNC05-2090 hydrochloride inhibits GAT-1, GAT-2 and GAT-3 with IC50s of 29.62, 45.29 and 22.51 μM respectively.[1]
In vivo	NNC05-2090 hydrochloride (i.p.; PSL mice) dose-dependently protects mice from maximal electric shock (MES) ED50 of 73 μmol/kg and against tonic and clonic convulsions in DBA/2 mice with an ED50 of 19 μmol /kg and 26 μmol/kg.[1] NNC05-2090 hydrochloride (0.01, 0.1, 0.3 mg/kg; intraperitoneal or intrathecal injection; once) can dose-dependently reverse mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.[2]

Chemical Properties

Molecular Weight	451
Formula	C27H31ClN2O2
Cas No.	184845-18-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 5.64 mg/mL

DMSO: 50 mg/mL (110.86 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2173 mL	11.0865 mL	22.1729 mL	110.8647 mL
5 mM	0.4435 mL	2.2173 mL	4.4346 mL	22.1729 mL
10 mM	0.2217 mL	1.1086 mL	2.2173 mL	11.0865 mL
20 mM	0.1109 mL	0.5543 mL	1.1086 mL	5.5432 mL
50 mM	0.0443 mL	0.2217 mL	0.4435 mL	2.2173 mL
100 mM	0.0222 mL	0.1109 mL	0.2217 mL	1.1086 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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