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NNC 05-711
🥰Excellent
Catalog No. T23075Cas No. 145645-62-1
Alias NO-711 hydrochloride, NNC05-711, NNC 05711
NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects.
NNC 05-711
🥰Excellent
Purity: 99.92%
Catalog No. T23075Alias NO-711 hydrochloride, NNC05-711, NNC 05711Cas No. 145645-62-1
NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $63 | In Stock | |
| 5 mg | $167 | In Stock | |
| 10 mg | $248 | In Stock | |
| 25 mg | $419 | In Stock | |
| 50 mg | $597 | In Stock | |
| 100 mg | $863 | In Stock | |
| 200 mg | $1,160 | In Stock |
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CitedSelect Batch
Purity:99.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects. |
| In vitro | Treatment of microglia with NNC 05-711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake in microglia. [1] |
| In vivo | Methods: NNC 05-711 (50, 100, 200 μg/10 μL, intrathecal injection, once a day) was used to treat rats with chronic sciatic nerve constriction injury (CCI) and its analgesic effect was observed. Results: NNC 05-711 exerted an effective analgesic effect in the CCI rat model. Compared with the CCI + saline group, the paw withdrawal threshold (WT) and paw withdrawal latency (WL) values increased after 1 day. [3] |
| Alias | NO-711 hydrochloride, NNC05-711, NNC 05711 |
| Molecular Weight | 386.87 |
| Formula | C21H23ClN2O3 |
| Cas No. | 145645-62-1 |
| Smiles | Cl.OC(=O)C1=CCCN(CCON=C(c2ccccc2)c2ccccc2)C1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (5.17 mM), Sonication is recommended. DMSO: 80 mg/mL (206.79 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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