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NO 711
🥰Excellent
Catalog No. T70414Cas No. 159094-94-7
Alias NO711, NNC-711 free acid
NO 711（NNC-711 free acid） is a potent and selective inhibitor of GABA transporter 1 (GAT-1), which increases GABAergic transmission, enhances non-rapid eye movement sleep, and prevents and treats paclitaxel-induced neuropathic pain.
NO 711
🥰Excellent
Purity: 99.83%
Catalog No. T70414Alias NO711, NNC-711 free acidCas No. 159094-94-7
NO 711（NNC-711 free acid） is a potent and selective inhibitor of GABA transporter 1 (GAT-1), which increases GABAergic transmission, enhances non-rapid eye movement sleep, and prevents and treats paclitaxel-induced neuropathic pain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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CitedSelect Batch
Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NO 711（NNC-711 free acid） is a potent and selective inhibitor of GABA transporter 1 (GAT-1), which increases GABAergic transmission, enhances non-rapid eye movement sleep, and prevents and treats paclitaxel-induced neuropathic pain. |
| In vitro | Treatment of microglia with NO 711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake. [2] |
| In vivo | Methods: 12-, 18-, and 25-day-old rat pups with implanted electrodes were used. Epileptic foci were induced by local application of dithiothreitol methyl iodide (BMI) via an implanted cannula over the sensorimotor cortical area, and cortical afterepileptic discharges (ADs) were induced by low-frequency stimulation (8 Hz) of the same cortical area. Epileptic foci were formed after pretreatment with NO 711 (1 or 10 mg/kg, i.p.), and epileptic ADs were induced in a second experimental series. NNC-711 was then applied at the same dose, and stimulation was repeated. Results: NO 711 did not block the formation of epileptogenic foci, but it significantly inhibited the spontaneous transition of interictal focal to ictal activity in all age groups. In 18- and 25-day-old rats, the intensity of movements accompanying sensorimotor cortical stimulation was smaller under the influence of NNC-711. [1] |
| Alias | NO711, NNC-711 free acid |
| Molecular Weight | 350.41 |
| Formula | C21H22N2O3 |
| Cas No. | 159094-94-7 |
| Smiles | OC(=O)C1=CCCN(CCON=C(c2ccccc2)c2ccccc2)C1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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