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OD36

OD36
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Purity:99.89%
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OD36

Catalog No. T35694Cas No. 1638644-62-8
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.
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Pack SizePriceAvailabilityQuantity
1 mg$68In Stock
5 mg$163In Stock
10 mg$247In Stock
25 mg$413In Stock
50 mg$619In Stock
100 mg$932In Stock
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Product Introduction

Bioactivity
Description
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.
Targets&IC50
ALK2 (R206H):22 nM (IC50), ALK2:37 nM (Kd), RIPK2:5.3 nM (IC50), ALK2:47 nM (IC50)
In vitro
OD36 shows activity against ALK1 (KD=90 nM).[2]
OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2]
OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2]
OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2]
In vivo
OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically neutrophils, and to a lesser extent, lymphocytes. It decreased RIPK2-specific genes, as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3]
AliasOD 36, OD 36 hydrochloride, OD-36
Chemical Properties
Molecular Weight330.77
FormulaC16H15ClN4O2
Cas No.1638644-62-8
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0232 mL15.1162 mL30.2325 mL151.1624 mL
5 mM0.6046 mL3.0232 mL6.0465 mL30.2325 mL
10 mM0.3023 mL1.5116 mL3.0232 mL15.1162 mL
20 mM0.1512 mL0.7558 mL1.5116 mL7.5581 mL
50 mM0.0605 mL0.3023 mL0.6046 mL3.0232 mL

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