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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $68 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $247 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $619 | In Stock | |
100 mg | $932 | In Stock |
Description | OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. |
Targets&IC50 | ALK2 (R206H):22 nM (IC50), ALK2:37 nM (Kd), RIPK2:5.3 nM (IC50), ALK2:47 nM (IC50) |
In vitro | OD36 shows activity against ALK1 (KD=90 nM).[2] OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2] OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2] OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2] |
In vivo | OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically neutrophils, and to a lesser extent, lymphocytes. It decreased RIPK2-specific genes, as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3] |
Alias | OD 36, OD 36 hydrochloride, OD-36 |
Molecular Weight | 330.77 |
Formula | C16H15ClN4O2 |
Cas No. | 1638644-62-8 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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