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ONO-7300243

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COA HNMR

ONO-7300243

Catalog No. T7393Cas No. 638132-34-0

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$88	In Stock
10 mg	$135	In Stock
25 mg	$272	In Stock
50 mg	$438	In Stock
100 mg	$689	In Stock
1 mL x 10 mM (in DMSO)	$90	In Stock

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Product Introduction

Bioactivity

Description	ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
Targets&IC50	LPA1:0.19-0.13 μM (IC50)
In vivo	The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p < 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].

Chemical Properties

Molecular Weight	461.55
Formula	C28H31NO5
Cas No.	638132-34-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (216.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1666 mL	10.8331 mL	21.6661 mL	108.3306 mL
5 mM	0.4333 mL	2.1666 mL	4.3332 mL	21.6661 mL
10 mM	0.2167 mL	1.0833 mL	2.1666 mL	10.8331 mL
20 mM	0.1083 mL	0.5417 mL	1.0833 mL	5.4165 mL
50 mM	0.0433 mL	0.2167 mL	0.4333 mL	2.1666 mL
100 mM	0.0217 mL	0.1083 mL	0.2167 mL	1.0833 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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