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OPC-28326

🥰Excellent
Catalog No. T13804Cas No. 167626-17-7

OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.

OPC-28326

OPC-28326

🥰Excellent
Purity: 98.56%
Catalog No. T13804Cas No. 167626-17-7
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$197 In Stock
5 mg$479 In Stock
10 mg$653 In Stock
25 mg$990 In Stock
50 mg$1,330 In Stock
100 mg$1,750 In Stock
200 mg$2,370 In Stock
1 mL x 10 mM (in DMSO)$597 In Stock
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Purity:98.56%
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Product Introduction

Bioactivity
Description
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.
Targets&IC50
α2A-adrenoceptor:2040 nM (ki), α2C-adrenoceptor:55 nM (ki), α2B-adrenoceptor:285 nM (ki)
In vitro
OPC-28326 augments microvessel growth and improves endothelial tube formation. OPC-28326 dose-dependently induces phosphorylation of eNOS and Akt without affecting total amounts of eNOS and Akt in HAECs[1].
In vivo
OPC-28326 improves blood flow recovery in murine hindlimb ischemia and increases the number of capillaries in the ischemic leg[1]. In rats, intravenous administration of OPC-28326 (3 - 30 mg/kg) and yohimbine (0.3 - 3 mg/kg) results in a dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920 without affecting the mydriasis[2].
Chemical Properties
Molecular Weight421.58
FormulaC26H35N3O2
Cas No.167626-17-7
SmilesC(=O)(C1=CC(C)=C(NC(CC)=O)C(C)=C1)N2CCC(N(CCC3=CC=CC=C3)C)CC2
Relative Density.1.13 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.22 mg/mL (10.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3720 mL11.8601 mL23.7203 mL118.6015 mL
5 mM0.4744 mL2.3720 mL4.7441 mL23.7203 mL
10 mM0.2372 mL1.1860 mL2.3720 mL11.8601 mL

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