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ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $54 | In Stock | |
2 mg | $76 | In Stock | |
5 mg | $136 | In Stock | |
10 mg | $246 | In Stock | |
25 mg | $475 | In Stock | |
50 mg | $695 | In Stock | |
100 mg | $988 | In Stock | |
500 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $136 | In Stock |
Description | ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM. |
Targets&IC50 | LSD1/KDM1A:20 nM |
In vitro | In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1] |
In vivo | In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1] |
Alias | RG-6016, ORY-1001, ORY 1001 |
Molecular Weight | 303.27 |
Formula | C15H22N2·2HCl |
Cas No. | 1431326-61-2 |
Smiles | Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (32.97 mM), Sonication is recommended. Ethanol: 1 mg/mL (3.3 mM) H2O: 56 mg/mL (184.7 mM) | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
DMSO/H2O
H2O
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