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ORY1001
Catalog No. T6922Cas No. 1431326-61-2
Alias RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001
ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
ORY1001
Catalog No. T6922Alias RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001Cas No. 1431326-61-2
ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $54 | In Stock | |
| 2 mg | $76 | In Stock | |
| 5 mg | $136 | In Stock | |
| 10 mg | $246 | In Stock | |
| 25 mg | $475 | In Stock | |
| 50 mg | $695 | In Stock | |
| 100 mg | $988 | In Stock | |
| 500 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $136 | In Stock |
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Purity:99.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM. |
| Targets&IC50 | LSD1/KDM1A:20 nM |
| In vitro | In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1] |
| In vivo | In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1] |
| Alias | RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001 |
| Molecular Weight | 303.27 |
| Formula | C15H22N2·2HCl |
| Cas No. | 1431326-61-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (32.97 mM), Sonication is recommended.  Ethanol: 1 mg/mL (3.3 mM) H2O: 56 mg/mL (184.7 mM) | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
DMSO/H2O
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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