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PARP-1-IN-3
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases.
Catalog No. T78157Cas No. 2976342-33-1
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Purity:98.38%
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PARP-1-IN-3
Catalog No. T78157Cas No. 2976342-33-1
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $248 | In Stock | |
| 50 mg | $368 | In Stock | |
| 100 mg | $543 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases. |
| Targets&IC50 | NCM460 cells:486.87 μM, HCT116 cells:0.30 μM, DLD-1 cells:2.83 μM, PARP1:0.25 nM, SW480 cells:33.69 μM, PARP2:2.34 nM |
| In vitro | PARP-1-IN-3 (compound 13f) demonstrates effective anticancer activity with IC50 values of 0.30 μM, 2.83 μM, 33.69 μM, and 486.87 μM against HCT116, DLD-1, SW480, and NCM460 cells, respectively, following a 48-hour treatment[1]. In HCT116 cells, PARP-1-IN-3 (0.3-3 μM) inhibits colony formation and migration over 24-48 hours[1]. A 48-hour treatment with PARP-1-IN-3 (0.3-3 μM) induces the accumulation of DNA double-strand breaks in HCT116 cells[1]. Treatment with PARP-1-IN-3 (0.3-7.5 μM) for 48-72 hours results in cell cycle arrest at the G2/M phase, reduced mitochondrial membrane potential, and apoptosis in HCT116 cells[1]. |
| Molecular Weight | 425.28 |
| Formula | C21H17BrN2O3 |
| Cas No. | 2976342-33-1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (235.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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