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PD-118057

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Purity:99.16%

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COA HNMR HPLC LCMS

PD-118057

Catalog No. T16444Cas No. 313674-97-4

PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$213	In Stock
10 mg	$328	In Stock
25 mg	$628	In Stock
50 mg	$997	In Stock
100 mg	$1,590	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock

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Product Introduction

Bioactivity

Description	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.
In vitro	PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in acutely isolated guinea pig ventricular cardiomyocytes.[1][2] At 10 μM, PD-118057 counteracts the current inhibition caused by Dof and Mox, preserves the unaltered 'hump' shape of the IKr current, and shows only a marginal increase in the maximum value of the suppressed current.[2]

Chemical Properties

Molecular Weight	386.27
Formula	C21H17Cl2NO2
Cas No.	313674-97-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (233.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5889 mL	12.9443 mL	25.8886 mL	129.4431 mL
5 mM	0.5178 mL	2.5889 mL	5.1777 mL	25.8886 mL
10 mM	0.2589 mL	1.2944 mL	2.5889 mL	12.9443 mL
20 mM	0.1294 mL	0.6472 mL	1.2944 mL	6.4722 mL
50 mM	0.0518 mL	0.2589 mL	0.5178 mL	2.5889 mL
100 mM	0.0259 mL	0.1294 mL	0.2589 mL	1.2944 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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