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PD128907 HCl

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PD128907 HCl

Catalog No. T6142Cas No. 112960-16-4

PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

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Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$107	In Stock
10 mg	$165	7-10 days
25 mg	$278	7-10 days
50 mg	$413	7-10 days

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Product Introduction

Bioactivity

Description	PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
In vitro	PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3]
In vivo	PD128907 HCl is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD128907 HCl (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6]

Chemical Properties

Molecular Weight	285.77
Formula	C14H20ClNO3
Cas No.	112960-16-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: <1 mg/mL

H2O: 46 mg/mL (161 mM)

DMSO: 10 mg/mL (35 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4993 mL	17.4966 mL	34.9932 mL	174.9659 mL
5 mM	0.6999 mL	3.4993 mL	6.9986 mL	34.9932 mL
10 mM	0.3499 mL	1.7497 mL	3.4993 mL	17.4966 mL
20 mM	0.1750 mL	0.8748 mL	1.7497 mL	8.7483 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0700 mL	0.3499 mL	0.6999 mL	3.4993 mL
100 mM	0.0350 mL	0.1750 mL	0.3499 mL	1.7497 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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