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PD 198306

Catalog No. T21980 CAS 212631-61-3

PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.

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PD 198306, CAS 212631-61-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 236.00
10 mg	In stock	$ 346.00
25 mg	In stock	$ 581.00
50 mg	In stock	$ 829.00
100 mg	In stock	$ 1,150.00
500 mg	In stock	$ 2,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 273.00

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Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.
In vitro	PD 198306 (10 μM) reduces Tha-Crimson replication by 30% at 18 h and 50% at 36 h. PD 198306 (10 μM) significantly inhibits Tha-GFP replication by 25%[1].
In vivo	In male Sprague Dawley rats bearing neuropathic pain, PD 198306 (1-30 μg/10 μL; i.t.) dose-dependently blocks static allodynia in both the chronic constriction injury and the streptozocin models[2].

Molecular Weight	476.23
Formula	C18H16F3IN2O2
CAS No.	212631-61-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (94.49 mM)

References and Literature

1. Benoit Besson, et al. Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection. mSphere. 2019 May 22;4(3):e00047-19. 2. A Ciruela, et al. Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br J Pharmacol. 2003 Mar;138(5):751-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compound Library Anti-Obesity Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Ovarian Cancer Compound Library

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Keywords

PD 198306 212631-61-3 MAPK MEK inhibit neuropathic Inhibitor MAP2K rabies mitogen-activated protein drug MAPKK phosphatases inositol RNA pain PD198306 interference ERK antihyperalgesic screening Mitogen-activated protein kinase kinase phosphate kinases PD-198306 inhibitor

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