phosphate

Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1,1'-(hydrogen phosphate) is a compound that is a phosphoric acid derivative of compound statins.

Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).

Potassium dihydrogen phosphate is a potassium salt in which dihydrogen phosphate(1-) is the counterion. It has a role as a fertilizer. It is a potassium salt and an inorganic phosphate.

L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.

Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.

Diethyl phosphate (Diethyl phosphoric acid), a Non-Specific Metabolite of Organophosphorus Pesticides.

Quercetin-3'-o-phosphate TEA (Quercetin 3'-phosphate TEA) is an adenosine A receptor antagonist that can be used to prevent and treat metabolic disorders.

Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.

Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia.

NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.

Glycerol 3-phosphate biscyclohexylammonium salt is an endogenous metabolite produced by cytosolic glycerol 3-phosphate dehydrogenase pathway.

Bis(4-nitrophenyl) phosphate (BNPP) inhibits UDP-galactose and can be used to study glycosyltransferase membrane topology.

NADH disodium salt hydrate is a coenzyme of oxidoreductase. NADH acts as a regenerative electron donor during catabolic processes including glycolysis, the citric acid cycle and beta-oxidation.

In cells, D-Glucose 6-phosphate potassium salt (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the beginning of both glycolysis and the pentose phosphate pathways. It also can be stored as glycogen when blood glucose levels are high.

Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) mainly exists in the skeletal muscles of vertebrates. It is a substrate for the determination of creatine kinase and can be used for the regeneration of ATP during skeletal muscle contraction.

Dihydroxyacetone phosphate hemimagnesium salt hydrate is also known as dihydroxyacetone phosphate or 3-hydroxy-2-oxopropyl phosphate. Dihydroxyacetone phosphate hemimagnesium salt hydrate is found in all organisms from bacteria to humans. In humans, Dihydroxyacetone phosphate hemimagnesium salt hydrate is involved in many enzymatic reactions. Dihydroxyacetone phosphate hemimagnesium salt hydrate has been studied for the treatment of lymphoma, large cell lymphoma, and diffuse lymphoma.

Ganaplacide phosphate exerts multi-stage antimalarial activity against Plasmodium symptomatic asexual blood-stage infections, and is able to prevent transmission and block infection in animal models.

Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.

D-erythrose 4-sodium phosphate is the sodium phosphate of the monosaccharide erythrose. Erythritol is actually converted to D-erythrose 4-phosphate involving three isomerases.

Riboflavine phosphate (Flavin mononucleotide) is a derivative of Riboflavin. Riboflavin phosphate can be used to study keratoconus, corneal dilatation, and irregular astigmatism. Riboflavine phosphate is an efficient and economical recycler of NAD+.

Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.

Ribose 5-phosphate is the intermediate product of the oxidative branch of the pentose phosphate pathway (PPP) and the final product of the non-oxidative branch of PPP. Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA), an endogenous metabolite, is utilized in the research of non-alcoholic fatty liver disease [1].

α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-D-tyvelose biosynthesis inS. typhi.3Bacterial sucrose phosphorylase converts sucrose and phosphate into D-fructose and α-D-glucose-1-phosphate.4 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen breakdown requires the interplay of several enzymesBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002) 3.Koropatkin, N.M., and Holden, H.M.Molecular structure of ɑ-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhiJ. Biol. Chem.279(42)44023-44029(2004) 4.Goedl, C., Schwarz, A., Minani, A., et al.Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of ɑ-Ｄ-glucose 1-phosphateJ. Biotechnol.129(1)77-86(2007)

Tricresyl phosphate is an organophosphate compound. It is used as a plasticizer and diverse other applications.

N-Acetyl-α-D-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, plays a crucial role as an intermediate in the biosynthesis of N-linked glycoproteins. Additionally, it serves as a metabolic precursor for the synthesis of bacterial cell-wall components, particularly teichoic acid and murein [1].

D-Glyceraldehyde 3-phosphate (Triose phosphate), a pivotal molecule in cellular metabolism, serves as a crucial intermediate in both glycolysis and gluconeogenesis, and as a sugar derivative in the Calvin cycle. Additionally, it plays a significant role in the biosynthesis of tryptophan and thiamin [1].

1,2-Dipalmitoyl-sn-glycerol 3-phosphate, a phosphatidic acid, is a human endogenous metabolite.

D-Sedoheptulose 7-phosphate is a common precursor of heptaic acid (group III) and hygromycin B (group IV) heptasaccharide. D-heptadecane 7-phosphate can be converted to NDP-heptose by similar biosynthetic pathways in these compounds.

Phosphate acetyltransferase, a transferase enzyme utilized in biochemical research, catalyzes the reversible acetylation of CoA from acetyl-P, yielding acetyl-CoA and inorganic phosphate. This process is integral to acetate assimilation/dissimilation reactions [1].

Sphinganine 1-phosphate, also known as D-erythro-Dihydrosphingosine 1-phosphate, is a polar sphingolipid metabolite. It plays a crucial role in regulating various cellular processes including cell migration, differentiation, survival, and complex physiological processes.

Etoposide phosphate disodium (BMY-40481 disodium), a phosphate ester prodrug of etoposide, functions as a potent chemotherapeutic agent by selectively inhibiting topoisomerase II, hindering the re-ligation of DNA strands. It is regarded as the active equivalent of etoposide, effectively inducing cell cycle arrest, apoptosis, and autophagy in cancer cells.

Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is al

BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).

D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway. [1] [2] In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate . D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics. [3]

D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(4)P1 can be formed by dephosphorylation of Ins(1,4)P2 by inositol polyphosphate 1-phosphatase or dephosphorylated to inositol by inositol monophosphatase.

Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.

Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered topically or subcutaneously at doses of 0.01-1% or 1 mg/kg, respectively.3It increases maximal lung pressure volume curves in fetal sheep when administered to pregnant ewes at 0.75 gestation at doses of 80 and 170 μg/kg.1Betamethasone 21-phosphate increases body weight, impairs learning and memory, increases anxiolytic behavior, and reduces hippocampal neurogenesis in CD-1 mice but reduces body weight and increases neurogenesis with no effect on anxiety in high-anxiety DBA/2 mice when administered at a dose of approximately 25 mg/kg per day in the drinking water for seven weeks.4Formulations containing betamethasone 12-phosphate and betamethasone acetate have been used in the treatment of severe allergic conditions and a variety of immune-related conditions. 1.Loehle, M., Schwab, M., Kadner, S., et al.Dose-response effects of betamethasone on maturation of the fetal sheep lungAm. J. Obstet. Gynecol.202(2)186.e181-186.e187(2010) 2.Leusink-Muis, A., Ten Broeke, R., Folkerts, G., et al.Betamethasone prevents virus-induced airway inflammation but not airway hyperresponsiveness in guinea pigsClin. Exp. Allergy29(Suppl. 2)82-85(1999) 3.Tsuji, F., Sawa, K., Kato, M., et al.The effects of betamethasone derivatives on endotoxin-induced uveitis in ratExp. Eye Res.64(1)31-36(1997) 4.Aiello, R., Crupi, R., Leo, A., et al.Long-term betamethasone 21-phosphate disodium treatment has distinct effects in CD1 and DBA/2 mice on animal behavior accompanied by opposite effects on neurogenesisBehav. Brain Res.278155-166(2015)

D-erythritol 4-phosphate is a phosphorylated component isolated from the hydrolysate.

D-Glucosamine 6-phosphate, an endogenous metabolite produced by glutamine fructose-6-phosphate amidotransferase (GFAT), is utilized in studies related to diabetes mellitus [1].

D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.

Glycerol-3-phosphate oxidase, a crucial intermediate in glycerol metabolism, can be extracted from Escherichia coli. It serves as the backbone for phospholipids in membrane lipids and acts as a substrate in the respiratory chain, generating electrons through oxidation [1].

D-glucose 6-phosphate is glucose that is phosphorylated on the carbon 6 hydroxyl group.

1-Naphthyl phosphate potassium salt inhibits non-specific phosphatase.

Glucocorticoid Receptor Agonist-1 Phosphate Gly-Glu (TFA) serves as a cleavable linker for the synthesis of Antibody-Drug Conjugates (ADCs).

Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such as antioxidant pathways, nitric oxide synthase, NADPH oxidase, and the cytochrome p450 system, among others. Its significance extends to research applications in diabetes, aldosterone-induced endothelial dysfunction, and cancer [1].

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), known as an active form of vitamin B6, is a coenzyme involved in many enzymatic reactions.

Iproniazid Phosphate is a non-selective, irreversible monoamine oxidase inhibitor (MAOI).

KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).