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KN-92 phosphate

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Purity:99.31%

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COA HNMR LCMS

KN-92 phosphate

Catalog No. T4530Cas No. 1135280-28-2

KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

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Pack Size	Price	Availability
1 mg	$47	In Stock
2 mg	$68	In Stock
5 mg	$139	In Stock
10 mg	$222	In Stock
25 mg	$376	In Stock
50 mg	$559	In Stock
100 mg	$786	In Stock
1 mL x 10 mM (in DMSO)	$168	In Stock

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Product Introduction

Bioactivity

Description	KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
Targets&IC50	CaMK II:370 nM(ki)
In vitro	KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.
Alias	KN92-H3PO4

Chemical Properties

Molecular Weight	554.98
Formula	C24H28ClN2O7PS
Cas No.	1135280-28-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (99.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8019 mL	9.0093 mL	18.0187 mL	90.0933 mL
5 mM	0.3604 mL	1.8019 mL	3.6037 mL	18.0187 mL
10 mM	0.1802 mL	0.9009 mL	1.8019 mL	9.0093 mL
20 mM	0.0901 mL	0.4505 mL	0.9009 mL	4.5047 mL
50 mM	0.0360 mL	0.1802 mL	0.3604 mL	1.8019 mL

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