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Trifluoperazine dihydrochloride
🥰Excellent
Catalog No. T1222Cas No. 440-17-5
Alias Urinox, Trifluoperazine 2HCl, SKF5019
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
Trifluoperazine dihydrochloride
🥰Excellent
Purity: 100%
Catalog No. T1222Alias Urinox, Trifluoperazine 2HCl, SKF5019Cas No. 440-17-5
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $50 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. |
| Targets&IC50 | D2 receptor:1.1 nM |
| In vitro | Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5] |
| In vivo | Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6] |
| Alias | Urinox, Trifluoperazine 2HCl, SKF5019 |
| Molecular Weight | 480.43 |
| Formula | C21H26Cl2F3N3S |
| Cas No. | 440-17-5 |
| Smiles | Cl.CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 88 mg/mL (183.2 mM) DMSO: 82 mg/mL (170.7 mM) Ethanol: 89 mg/mL (185.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Trifluoperazine dihydrochlorideTrifluoperazine DihydrochlorideTrifluoperazineSKF-5019SKF 5019schizophreniaP-gp (P-glycoprotein)P-gpPgpP-glycoproteinNUPR1Multidrug resistance protein 1morphogenesisMDR1InhibitorinhibitInfluenzaVirusInfluenza VirusDopamineReceptorDopamine ReceptorDopamineD2Cluster of differentiation 243CD243CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesBeta ReceptorAutophagyantipsychoticanticancerAdrenergicReceptorAdrenergic ReceptorABCB1
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