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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $57 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $148 | In Stock | |
50 mg | $226 | In Stock | |
100 mg | $337 | In Stock | |
200 mg | $491 | In Stock | |
1 mL x 10 mM (in DMSO) | $87 | In Stock |
Description | Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines. |
Targets&IC50 | Calmodulin:3 nM(kd), Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM, PDE (CaM-dependent):0.15 μM, Calmodulin:12.69 μM(mouse E14 ESCs), Calmodulin:8.18 μM(mouse F9 ECCs) |
In vitro | Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2]. |
Alias | R 24571 |
Molecular Weight | 687.7 |
Formula | C31H23Cl7N2O |
Cas No. | 57265-65-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (145.41 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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