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Calmidazolium chloride
🥰Excellent
Catalog No. T10667Cas No. 57265-65-3
Alias R 24571
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
Calmidazolium chloride
🥰Excellent
Purity: 98.06%
Catalog No. T10667Alias R 24571Cas No. 57265-65-3
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $57 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $148 | In Stock | |
| 50 mg | $226 | In Stock | |
| 100 mg | $337 | In Stock | |
| 200 mg | $491 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $87 | In Stock |
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Purity:98.06%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist with a Kd of 3 nM, which inhibits CaM-dependent phosphodiesterase (IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase (IC50 = 0.35 μM). It also induces apoptosis in certain cancer cell lines. |
| Targets&IC50 | PDE (CaM-dependent):0.15 μM, Calmodulin:12.69 μM(mouse E14 ESCs), Ca2+ transporting ATPase (erythrocyte, Calmodulin-induced):0.35 μM, Calmodulin:8.18 μM(mouse F9 ECCs), Calmodulin:3 nM(kd) |
| In vitro | Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2]. |
| Alias | R 24571 |
| Molecular Weight | 687.7 |
| Formula | C31H23Cl7N2O |
| Cas No. | 57265-65-3 |
| Smiles | [Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (145.41 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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