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KN-92 hydrochloride

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Catalog No. T8543Cas No. 1431698-47-3

KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.

KN-92 hydrochloride

KN-92 hydrochloride

🥰Excellent
Purity: 99.68%
Catalog No. T8543Cas No. 1431698-47-3
KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$106In Stock
10 mg$179In Stock
25 mg$297In Stock
50 mg$455In Stock
100 mg$645In Stock
1 mL x 10 mM (in DMSO)$115In Stock
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Purity:99.68%
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Product Introduction

Bioactivity
Description
KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.
Chemical Properties
Molecular Weight493.45
FormulaC24H26Cl2N2O3S
Cas No.1431698-47-3
SmilesCl.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)CC=Cc1ccc(Cl)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (81.06 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0265 mL10.1327 mL20.2655 mL101.3274 mL
5 mM0.4053 mL2.0265 mL4.0531 mL20.2655 mL
10 mM0.2027 mL1.0133 mL2.0265 mL10.1327 mL
20 mM0.1013 mL0.5066 mL1.0133 mL5.0664 mL
50 mM0.0405 mL0.2027 mL0.4053 mL2.0265 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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