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Piperazine Erastin

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Purity:97.74%

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COA HNMR HPLC

Piperazine Erastin

Catalog No. T16540Cas No. 1538593-71-3

Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.

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Pack Size	Price	Availability
1 mg	$88	In Stock
5 mg	$177	In Stock
10 mg	$297	In Stock
25 mg	$596	In Stock
50 mg	$977	In Stock
100 mg	$1,290	In Stock
200 mg	$1,770	In Stock
500 mg	$2,630	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Product Introduction

Bioactivity

Description	Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
In vitro	Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1].
In vivo	A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1].

Chemical Properties

Molecular Weight	645.19
Formula	C35H41ClN6O4
Cas No.	1538593-71-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (100.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5499 mL	7.7497 mL	15.4993 mL	77.4966 mL
5 mM	0.3100 mL	1.5499 mL	3.0999 mL	15.4993 mL
10 mM	0.1550 mL	0.7750 mL	1.5499 mL	7.7497 mL
20 mM	0.0775 mL	0.3875 mL	0.7750 mL	3.8748 mL
50 mM	0.0310 mL	0.1550 mL	0.3100 mL	1.5499 mL
100 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.7750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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