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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $347 | In Stock |
Description | Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors. |
In vitro | Pladienolide B (0.1-2 nM; 24-72 h; HeLa cells) decreases SF3b1 expression, induces cell cycle arrest and apoptosis, and suppresses cell viability in human cervical carcinoma cells in a concentration- and time-dependent manner. [3] |
In vivo | Pladienolide B (2.5-10 mg/kg; i.v.; daily for 5 days) demonstrated strong growth inhibitory or regressive activities against PC-3, OVCAR-3, DU-145, WiDr, and HCT-116, BSY-1 xenografts in BALB/c nu/nu mice, exhibiting intense antitumor activities.[4] |
Molecular Weight | 536.7 |
Formula | C30H48O8 |
Cas No. | 445493-23-2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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