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PRLX-93936 HCL

Catalog No. T36404L CAS 1094210-96-4

Synonyms: PRLX-93936 hcl(903499-49-0 Free base)

PRLX-93936 hcl is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

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PRLX-93936 HCL, CAS 1094210-96-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

PRLX-93936 hcl is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

In vitro

Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1].

Synonyms	PRLX-93936 hcl(903499-49-0 Free base)
Molecular Weight	437.37
Formula	C21H26Cl2N4O2
CAS No.	1094210-96-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50.00mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liang Z, et al. Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells. Biochem Biophys Res Commun. 2021 Sep 10;569:79-85.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PRLX-93936 HCL 1094210-96-4 NF-Κb Metabolism Immunology/Inflammation Cell Cycle/Checkpoint Apoptosis Ferroptosis Reactive Oxygen Species PRLX93936 HCL PRLX 93936 HCL PRLX-93936 hcl(903499-49-0 Free base) Inhibitor inhibitor inhibit

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