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PRLX-93936 HCL
Catalog No. T36404LCas No. 1094210-96-4
Alias PRLX-93936 hcl(903499-49-0 Free base)
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
PRLX-93936 HCL
Catalog No. T36404LAlias PRLX-93936 hcl(903499-49-0 Free base)Cas No. 1094210-96-4
PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $562 | In Stock | |
| 25 mg | $889 | In Stock | |
| 50 mg | $1,190 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 200 mg | $2,170 | In Stock |
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Purity:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin. |
| In vitro | Cotreatment with cisplatin and PRLX93936 induced ferroptosis, as evidenced by the upregulation of ROS, lipid peroxidation and Fe2+. Further investigation revealed that cotreatment with cisplatin and PRLX93936 inhibited GPX4 and that overexpression of GPX4 prevented cell death. Moreover, the Nrf2/Keap1 pathway also regulated the sensitivity to cisplatin and PRLX93936 in NSCLC cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it[1]. |
| Alias | PRLX-93936 hcl(903499-49-0 Free base) |
| Molecular Weight | 437.37 |
| Formula | C21H26Cl2N4O2 |
| Cas No. | 1094210-96-4 |
Storage & Solubility Information
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 50.00 mg/mL  |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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