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PU-H71

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Purity:98.31%

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COA HNMR HPLC LCMS

PU-H71

Catalog No. T6960Cas No. 873436-91-0

PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.

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Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$59	In Stock
50 mg	$198	7-10 days
100 mg	$354	7-10 days
1 mL x 10 mM (in DMSO)	$107	In Stock

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Product Introduction

Bioactivity

Description	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
In vitro	PU-H71(1 μ M) potently inhibits the growth of triple negative breast cancer (TNBC) cell lines MDA-MB-468, MDA-MB-231, and HCC-1806, with IC50 values of 65, 140, and 87 nM, respectively. PU-H71(1 μ M) kills 80%, 65%, and 80% of MDA-MB-468, MDA-MB-231, and HCC-1806 cells, respectively[1].
In vivo	MDA-MB-231 model treated with PU-H71 at a dose of 75 mg/kg was 100% fully effective. After 37 days of treatment, tumor was replaced by scar tissue, accompanied by a reduction in many proliferative and anti apoptotic molecules, such as EGFR, HER3, Raf-1, Akt, and p-Akt, which decreased by 80%, 95%, 99%, 80%, and 65%, respectively. PU-H71 (75 mg/kg, three times a week) inhibits tumor growth by 96%, reduces tumor cell proliferation by 60%, decreases activated Akt associated with survival and high invasive potential by 85%, and increases apoptosis by 6-fold[1].

Chemical Properties

Molecular Weight	512.37
Formula	C18H21IN6O2S
Cas No.	873436-91-0

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46.1 mg/mL (89.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9517 mL	9.7586 mL	19.5171 mL	97.5857 mL
5 mM	0.3903 mL	1.9517 mL	3.9034 mL	19.5171 mL
10 mM	0.1952 mL	0.9759 mL	1.9517 mL	9.7586 mL
20 mM	0.0976 mL	0.4879 mL	0.9759 mL	4.8793 mL
50 mM	0.0390 mL	0.1952 mL	0.3903 mL	1.9517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc