store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 82.00 | |
25 mg | In stock | $ 131.00 | |
50 mg | 5 days | $ 198.00 | |
100 mg | 5 days | $ 354.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM. |
Targets&IC50 | HSP90:51 nM |
In vitro | PU-H71(1 μ M) potently inhibits the growth of triple negative breast cancer (TNBC) cell lines MDA-MB-468, MDA-MB-231, and HCC-1806, with IC50 values of 65, 140, and 87 nM, respectively. PU-H71(1 μ M) kills 80%, 65%, and 80% of MDA-MB-468, MDA-MB-231, and HCC-1806 cells, respectively[1]. |
In vivo | MDA-MB-231 model treated with PU-H71 at a dose of 75 mg/kg was 100% fully effective. After 37 days of treatment, tumor was replaced by scar tissue, accompanied by a reduction in many proliferative and anti apoptotic molecules, such as EGFR, HER3, Raf-1, Akt, and p-Akt, which decreased by 80%, 95%, 99%, 80%, and 65%, respectively. PU-H71 (75 mg/kg, three times a week) inhibits tumor growth by 96%, reduces tumor cell proliferation by 60%, decreases activated Akt associated with survival and high invasive potential by 85%, and increases apoptosis by 6-fold[1]. |
Molecular Weight | 512.37 |
Formula | C18H21IN6O2S |
CAS No. | 873436-91-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.1 mg/mL (89.9 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PU-H71 873436-91-0 Cytoskeletal Signaling Metabolism HSP PUH71 PU H71 inhibitor inhibit