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PU-H71 HCl

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PU-H71 HCl

Catalog No. T6960LCas No. 2095432-24-7

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.

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Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$430	In Stock
10 mg	$636	In Stock
25 mg	$987	In Stock
50 mg	$1,360	In Stock
100 mg	$1,830	In Stock
500 mg	$3,680	In Stock

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Product Introduction

Bioactivity

Description

Alias

PU-H71 HCl(873436-91-0 Free base), Zelavespib HCl

Chemical Properties

Molecular Weight	548.83
Formula	C18H22ClIN6O2S
Cas No.	2095432-24-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (81.99 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8221 mL	9.1103 mL	18.2206 mL	91.1029 mL
5 mM	0.3644 mL	1.8221 mL	3.6441 mL	18.2206 mL
10 mM	0.1822 mL	0.9110 mL	1.8221 mL	9.1103 mL
20 mM	0.0911 mL	0.4555 mL	0.9110 mL	4.5551 mL
50 mM	0.0364 mL	0.1822 mL	0.3644 mL	1.8221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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