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Pyr6

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Purity:99.18%

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COA HPLC HNMR

Pyr6

Catalog No. T16688Cas No. 245747-08-4

Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.

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Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$52	In Stock
10 mg	$87	In Stock
25 mg	$143	In Stock
50 mg	$213	In Stock
100 mg	$319	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Product Introduction

Bioactivity

Description	Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.
In vitro	Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?By contrast, Pyr6 exhibited a 37-fold higher potency to inhibit Orai1-mediated Ca(2+) entry as compared with TRPC3-mediated Ca(2+) entry and potently suppressed mast cell activation.
Alias	N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

Chemical Properties

Molecular Weight	418.27
Formula	C17H9F7N4O
Cas No.	245747-08-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (227.12 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3908 mL	11.9540 mL	23.9080 mL	119.5400 mL
5 mM	0.4782 mL	2.3908 mL	4.7816 mL	23.9080 mL
10 mM	0.2391 mL	1.1954 mL	2.3908 mL	11.9540 mL
20 mM	0.1195 mL	0.5977 mL	1.1954 mL	5.9770 mL
50 mM	0.0478 mL	0.2391 mL	0.4782 mL	2.3908 mL
100 mM	0.0239 mL	0.1195 mL	0.2391 mL	1.1954 mL

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